Phosphorylated Lamins in Euchromatin: New Clues to Progeria
نویسندگان
چکیده
منابع مشابه
Proteins that bind A-type lamins: integrating isolated clues.
What do such diverse molecules as DNA, actin, retinoblastoma protein and protein kinase Calpha all have in common? They and additional partners bind 'A-type' lamins, which form stable filaments in animal cell nuclei. Mutations in A-type lamins cause a bewildering range of tissue-specific diseases, termed 'laminopathies', including Emery-Dreifuss muscular dystrophy and the devastating Hutchinson...
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A-type lamins are components of the peripheral nuclear lamina but also localize in the nuclear interior in a complex with lamina-associated polypeptide (LAP) 2α. Loss of LAP2α and nucleoplasmic lamins in wild-type cells increases cell proliferation, but in cells expressing progerin (a mutant lamin A that causes Hutchinson-Gilford progeria syndrome), low LAP2α levels result in proliferation defe...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2020
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2020.03.003